Real Dictionary

tire
If you tire of something, you no longer wish to do it, because you have become bored of it or unhappy with it.
countable noun: A tire is the same as a tyre.
verb: If something tires you or if you tire, you feel that you have used a lot of energy and you want to rest or sleep.

tire in American English 1
to become in need of rest; become weary or fatigued through exertion
intransitive verb: to have the strength reduced or exhausted, as by labor or exertion; become fatigued; be sleepy
noun: fatigue
transitive verb: to reduce or exhaust the strength of, as by exertion; make weary; fatigue

tire in American English 2
a hoop of iron or rubber around the wheel of a vehicle, forming the tread
noun: a ring or band of rubber, either solid or hollow and inflated, or of metal, placed over the rim of a wheel to provide traction, resistance to wear, or other desirable properties
transitive verb: to furnish with tires

tire in American English 3
attire
to attire or dress
noun: a headdress
transitive verb: to dress (the head or hair), esp. with a headdress

tire in Automotive Engineering
noun: A tire is a thick piece of rubber which is fitted onto the wheels of a vehicle.

tire in British English 1
verb: to reduce the energy of, esp by exertion; weary